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Home » Pharma Products » Alzheimer & Parkinson's Drugs

Alzheimer & Parkinson's Drugs

Both Alzheimer and Parkinson's disease are related with the Central Nervous System (CNS). Alzheimer disease is also termed as short term memory loss that results in deficit memory and also affects an individual thinking power and behavior. It's a neurodegenerative disease in which there are progressive deaths of the brain cell that can get worse with passing time. Whereas Parkinson's disease is also known as an Idiopathic or Primary Parkinsonism, as it is a degenerative disorder targeting specifically the motor system responsible for producing dopamine.
The cell death result in the rigidity of the body, shaking, trouble while moving and later can also result in dementia. The abnormality in the chemical substance called dopamine present in brain is the major cause of Alzheimer and Parkinson's. Our drugs are developed to increase the reuptake of dopamine, thereby, reducing the symptoms. Study shows some short term and common side effects associated with the Alzheimer and Parkinson's drugs such as drowsiness, nausea or vomiting, tremor and upset stomach.

Aricept

Aricept is a drug of choice for the treatment of mild, moderate and severe kind of Alzheimer disease. It contains Donepezil as an active ingredient that shows its action by preventing the breakdown of acetylcholine as it is a reversible inhibitor of this chemical.
On examination the people who are suffering from Alzheimer are diagnosed with less amount of acetylcholine, which is required for the process of thinking, memory and processing. It should be noted that Aricept does not cure Alzheimer while it helps in restoring balance of neurotransmitter in the brain.


If patient is suffering from any undesirable effect, they should immediately contact the physician. Some of the reported side effects are:
  • Occurrence of black, bloody or tarry stools
  • Vomiting with blood
  • Difficulty while urinating
  • Generation of Seizure
  • Patient can feel nausea or vomiting
  • Formation of stomach ulcer
  • Development of diarrhea, difficulty in sleeping or muscle cramps

  • Patient having any history of heart disease like sickle sinus syndrome or bradycardia should concern the physician before taking medicine
  • Patient with the liver or kidney disorder, any allergies, problem in urination or taking medicines for the treatment of seizure should concern the doctor first
  • If any person is already taking medicine for asthma, pulmonary disorder, dementia or for ulcer; should not take Aricept along with any of these as it can worsen the condition

Artane

Artane is a medicine primarily used for the management of Parkinson’s disease. Its main ingredient Trihexyphenidyl is one of effective centrally acting muscuranic antagonists that are used for relaxation of the stiffness, tremors, spasms and poor muscle control of Parkinson’s disease.
This medicine shows its mechanism by blocking the cholinergic action in CNS which is responsible for the occurrence of the Parkinson’s disease. Furthermore, it also plays an important role in treatment of abnormal muscular condition caused by some of the mentioned drugs like Chlorpromazine, Fluphenazine, Perphenazine, Haloperidol, Thiothixene and many others.


While taking medicine, patient can come across some of noted adverse reaction and it is not necessary that everyone can face this.


Severe side effects:
  • Allergic reactions such as swelling of lips, difficulty in breathing, chocking of throat and others
  • Development of fever
  • Irregular heartbeat
  • Generation of anxiety, hallucination, confusion, agitation, hyperactivity and even loss of consciousness
  • Uncontrollable body movements
  • Pain in eyes

Less known side effects:
  • Dryness of the mouth
  • Enlargement of pupils
  • Constipation and difficulty while urinating
  • Drowsiness or vertigo
  • Anxiety
  • Stomach problems
  • Decreased amount of sweating

  • Patients are advised to not take this medicine before driving, operating any heavy machinery or performing any hazardous activities as it results in dizziness
  • This medicine should not be taken with alcohol as Artane enhances drowsiness along with it
  • Doctor should know the medical history of patient before prescribing this medicine. This drug is not advisable in case of eye disease, ulcer problem, stomach related disorder or asthma
  • Avoid getting exposed to heat as it is reported that this medicine decrease the formation of sweating that could lead to heart attack

Dostinex

Dostinex is associated with the treatment of disorder related with high levels of prolactin hormone, either caused by formation of tumor in the pituitary gland or any other cause. Dostinex comprises cabergoline as main drug to show action that belongs to the class of medicine known as prolactin inhibitor.
The mechanism by which this medicine work is related with stimulation of D2 receptor available in anterior pituitary glands, thus prevent the excess production of prolactin. Dostinex is reported to treat different kind of medical problem related with prolactin resulting in menstrual problem and fertility problem in both men and women.


Rigorous side effects:

If patient faces any kind of the mentioned unwanted reactions, then he should instantaneously seek the medical assistance.

  • Shortening of breath
  • Discomfort regarding chest
  • Loss of appetite resulting in weakness
  • Lower back pain
  • Decrease in the frequency of urination
  • Swelling in ankles

Mild side effects:
  • Nausea or vomiting
  • Dizziness
  • Decrease blood pressure
  • Constipation and stomach pain


Patient should take precaution while taking Dostinex as it can result in some of the severe conditions that can trouble patient.
  • It is advisable to not consume alcohol, drive or perform any heavy activity as it is reported that medicine causes drowsiness. To avoid this do your normal activities slowly and sit or lie at the first sign of these effects
  • Person should not take medicine if he is allergic to thus medicine or is on the prescription if any other anti allergic medicines
  • Pregnant ladies are not recommended with this drug as it can affect the unborn baby
  • Dostinex is given to the children with extreme cautions until they are diagnosed with the Hyperprolactinemia
  • Patient with the history of heart disease, liver disorder or lung disease should previously tell their doctor about these diseases

Eldepryl

Eldepryl plays an important role in the management of Parkinson ’s disease. The main active constituent of this medicine is Selegiline as it is an irreversible inhibitor of monoamino oxidase type B (MAO B). Thus, Eldepryl prevents the breakdown of dopamine present in the brain by slowing the mechanism.
Patient diagnosed with the Parkinson’s are prescribed with this medicine in combination with Levodopa or Cabidopa that improvises the tremor, muscle stiffness, loss of normal movement and other activities also.


Patient can suffer some of the given side effects but it varies from patient to patient and also it is not necessary that all of the side effects occur.
  • Headache
  • Patient get confused and hallucination can occur
  • Problem with speech or balance
  • Seizure
  • Patient can feel tiredness, irritability or agitation
  • Painful or difficult urination
  • Twitching muscle movement
  • Dizziness
  • Running nose
  • Pain in back
  • Development of ulcer in mouth
  • Stomach problems like ulcer

  • If patient is on the prescription of over-the-counter medicine like vitamins, herbal medicine or minerals, then doctor must take precaution while prescribing medicine
  • Tailor made medicine should not be taken and never stop medicine until the doctor says so
  • Patient allergic to Selegiline should not take this medicine as it can lead to some harmful effects
  • Never take this medicine along with alcohol and also it is advisable to not drive or operate any heavy machinery because the drug has the side effect of causing dizziness

Exelon

Exelon has the dual advantage of working in management of both Alzheimer and Parkinson’s disorder. Exelon works by showing its action on preventing the breakdown of acetylcholine in brain required for the process of memory, thinking and progressing.
It basically prescribed to patient having dementia developed due to above mentioned disorders. The main ingredient which composes this medicine is Rivastigmine that does not cure the disease but improvise memory awareness so that patients can do their daily functions normally.


In case of development of any kind of side effect, it is advisable to seek the medical attention.
  • Bloody or tarry stool
  • Skin irritation, redness
    or itching
  • Painful urination
  • Uncontrolled shaking
  • Nausea or vomiting
  • Headache
  • Loss of appetite
  • Weakness
  • Hallucination and confusion
  • Cough with blood
  • Chest pain
  • Stomach upset


Patient has to be little more precautions in certain circumstances that can lead to some unwanted consequences.
  • Patients should inform their doctor regarding medical history of heart disease, liver or kidney disorder and any kind or lung problem
  • Person allergic to Rivastigmine should not go for this medicine as it can cause allergic reactions
  • Exellon can impair your thinking power, so it is advisable to not operate any heavy machinery, perform any dangerous activity or drive also
  • Exelon should also not to be taken if patient is already suffering from skin problem

Kemadrin

For the management of Parkinson’s disease,Kemadrin is prescribed as therapeutic medicine. Procycline Hydrochloride present in Kemadrin is known for relaxing the smooth muscle, thus controlling the muscle spasm.
The active ingredient is an artificially produced antispasmodic of relatively low toxicity. It is prescribed for the symptomatic treatment of Parkinson’s and extrapyramidal dysfunction reported by tranquilizer therapy. It helps in controlling the stiff muscles, paralysis; trouble related with talking, walking and writing; also prescribed in case of depressed patient.


Most of medicines show the adverse reaction, but the severity depends on patient’s response to medicine. Thus, side effects of Kemadrin is categorize into below mentioned types.


Common side effects (affect 1 in 10 people)

  • Patient feel problem while urinating
  • Blurred vision
  • Dry mouth and constipation

Uncommon side effects (affect 1 in 100 people)
  • Nausea or vomiting
  • Gingivitis
  • Dizziness
  • Anxiety and loss of memory
  • Hallucinations or nervousness
  • Skin related problems

Rare side effects (affect 1 in 1000 people)
  • Hallucination and anxiety
  • Disorientation
  • confusion


  • Kemadrin is strictly prohibited to the women who are pregnant and lactating their babies.
  • It is not dispensed with other prescribed medicine and dietary supplements.
  • Kemadrin is reported to cause blurred vision; hence patients who are on the prescription of this medicine should not drive and perform any heavy activities.
  • Patient with the medical history of heart disease, lung disorder or liver and kidney insufficiency are not advised to take this medicine.
  • Individual allergic to the drug should not proceed with this medicine as it can result in allergic reactions.
  • Prescribing Kemadrin to the children should be done with extreme precautions.

Mirapex

Parkinson’s disease occurs due to the imbalance amount of dopamine in brain.Miraprex works as an agonist of dopamine that helps in restoring its balance. The key element in composition of Miraprex is Pramipexole that can be used alone or in combination with other medication.It accounts in improving ability to move and decrease tremor, stiffness, slowed movement and unsteadiness. In is also used in the management of RLS (Restless Leg Syndrome) that causes an unusual urge to move legs, thereby improving sleep.


  • Blurred vision
  • Drowsiness or dizziness
  • Tremors, twitching or
    unmanageable body movements
  • Unknown muscle pain
    or tenderness
  • Weakness
  • Loss of memory
  • Nausea or vomiting
  • Constipation
  • Muscle spasm
  • Swelling occurs in hand and feet
  • Increased frequency of urination
  • Headache
  • Chest pain


While taking Miraprex, patients should take some of the safety measure to avoid any undesirable effect.

  • If the person is allergic to Miraprex, then he should tell his doctor about the same to avoid any allergic reactions.
  • The drug causes blurred vision, thus, it is preferable to not drive or perform any heavy activity.
  • This drug should not be taken with alcohol as it can increase the drowsiness effect.
  • Patient who is on prescription of treatment of heart disease, liver or kidney disorder and any lung impairment should not take Miraprex as it worsen the condition.

Namenda

In the management of Alzheimer disease,Nameda is included in therapy as it reduces action of chemicals present in brain that may contribute to this syndrome. The key element of the Nameda is Memantine that is used for the treatment of dementia related with Alzheimer. Nameda is NMDA receptor antagonist that shows its mechanism by inhibiting the action of glutamate present in brain. It improvises the memory, thinking power and mental awareness to perform daily functions.


Call your doctor at once if you have:

  • Severe headache
  • Blurred vision
  • Seizure (convulsions)
  • Unusual changes in mood or behavior

Common side effects may include:

  • Diarrhea
  • Dizziness
  • Headache


Before taking medicine it is advisable to take extra precautions if:
  • Patient is allergic to Nameda, then do not take this medicine as it can result in the occurrence of allergic reaction.
  • Person with the history of heart related disorder, liver or kidney dysfunction and lung disease should not take this medicine.
  • Other prescription drug should not be prescribed with Nameda as it results in drug interaction.

Parlodel

The management of Parkinson’s disease can also be done with Parlodel that can be use alone or in combination with other medicine. The key element present in this drug is Bromocriptine mesylate that works by blocking the discharge of prolactin available in pituitary gland.
Parlodel is used in the management of hormonal problem resulted by high level of prolactin that affects the menstrual cycle and fertility in men and women both. In Parkinson disease, Parlodel works by stimulating dopamine receptors in certain parts of the brain.


Many of medicine available in the market show some sort of side effects and varies from patient to patient.
  • Cold sensitivity in fingers and toes
  • Trouble in vision
  • Tightness in chest
  • Swelling of mouth, lips or tongue
  • Abnormal involuntary movements
  • Changes in sexual ability or desire
  • Fainting or hallucination
  • Stomach disturbance
  • Sudden loss of coordination
  • Skin rashes
  • Confusion and hallucination


Do not use Parlodel if:
  • Person is allergic to Bromocriptine.
  • Women who are pregnant and lactating their babies.
  • Patient with hereditary problem of galactose intolerance, severe lactase deficiency or glucose-galactose malabsorption.
  • Patient who are already on the prescription of other medicine.
  • Patient with the history of heart, liver, kidney or lung disorder.
  • Patient with high blood pressure.

Reminyl

Galantamine is the main ingredient of Reminyl that improves the function of nerve cells present in brain. Medicine shows it works by preventing the breakdown of a chemical called acetylcholine, the substance involve in the development of dementia. People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning to perform daily function.
Galantamine is a reversible cholinesterase inhibitor for the treatment of mild to moderate level of dementia caused by Alzheimer disease. This medicine works by increasing the concentration of acetylcholine by preventing the hydrolysis of same.


  • Abdominal pain
  • Diarrhea
  • General feeling of being unwell
  • Headache
  • Leg cramps
  • Lightheadedness
  • Loss of appetite
  • Vomiting or nausea
  • Weight loss

Although most of these side effects listed below don't happen very often,they could lead to serious problems if you do not seek medical attention.So,in this condition seek the medical help:
  • Behavior changes
    (e.g., agitation, aggressiveness, confusion)
  • Chest pain
  • Difficulty swallowing
  • Dizziness or fainting
  • Hallucinations
  • High or low blood pressure
  • Abnormal bleeding
  • Dehydration
  • Depression
  • Urinary tract infection
  • Slow or irregular heartbeat
  • Unusual tiredness or weakness
  • Tremor


Patient are advised to inform their doctor of any medical consequences from which they are suffering in past.
  • Patient with the bladder problem should not take this medicine as it can result in urinary tract infection.
  • Patient with the heart disease like coronary heart disease is not advisable to take this medicine.
  • Patient with the medical history of kidney and liver dysfunction should not go for this drug as it can result in harmful effects.
  • Reminyl is not prescribed to patient with the problem of stomach ulcer.
  • This medicine is also not advised to the women who are pregnant or lactating he babies.
  • Children should be prescribed this medicine with extra precautions.
  • Alcohol should not be taken with Reminyl as it results in drowsiness and thus, patient should not drive any vehicle or do any heavy work.

Requip

Requip is indicated in idiopathic syndrome of Parkinson’s disease as it mimics the working of dopamine. The signs of Parkinson’s like stiffness of body, shaking and uncontrollable body movements can be controlled by taking this medicine.
Restless Leg Syndrome (RLS) can also be treated with this medicine. It shows it mechanism of action by binding to dopamine receptor in the brain, hence the main component of medicine Ropinorole stimulates the receptor and improvises the condition of Parkinson’s.


More common side effects:
  • Light headed feeling
  • Modification in behavior
  • Drowsiness or dizziness
  • Tremors
  • Unknown muscle pain
  • Weakness
  • Increased sexual urges,urge to gamble or
    intense urges while taking medicine
  • Chest pain
  • Palpitation

Common Side Effects may include:
  • Headache
  • Confusion
  • Hallucinations
  • Nausea or vomiting
  • Stomach disturbance
  • Flu symptoms (fever, chills, body aches)
  • Sudden muscle movements
  • Excessive amount of sweating
  • Swelling in legs or feet


To get preventive from any kind of undesirable effects, patient has to take some of the precautionary measure if he has some kind of serious medical past.
  • Requip is strictly prohibited to the women who are pregnant and lactating their babies as it passes to baby through womb or milk and hamper the growth of babies.
  • It is not prescribed with the other prescribed medicine and dietary supplements.
  • Requip is reported to cause blurred vision; hence patients who are on the prescription of this medicine should not drive and perform any heavy activities.
  • Patient with the medical history of heart disease, lung disorder or liver and kidney insufficiency are not advised to take this medicine.
  • Individual allergic to the drug should not proceed with this medicine as it can result in allergic reactions.
  • Prescribing Requip to the children should be done with extreme precautions.

Sinemet

Sinemet is the antidyskinetic combination of Carbidopa and Levodopa. The drug is primarily used in the management of idiopathic Parkinson’s and it’s like symptoms such as stiffness, shaking or difficulty in moving the muscle.
Parkinson’s disease mainly occurs when the amount of dopamine in brain gets decreased. Levodopa when reaches the brain gets converted into dopamine, thus controls the symptoms of Parkinson’s. Whereas, Carbidopa prevents the breakdown of levodopa in bloodstream; hence increasing the availability of levodopa in brain.

  • Skin rashes
  • Difficulty in breathing
  • Abnormal heart beat
  • Behavioral changes
  • Stomach pain
  • Bloody vomiting
  • Yellowing of skin and eyes
  • Tiredness
  • Dizziness
  • Tightness in chest
  • Unusual spasm of face, eyelids and other parts


Patient are advised to inform their doctor of any medical consequences from which they are suffering in past.
  • Patient with the skin problem should not take this medicine as it can result in harmful effects.
  • Patient with the heart disease like coronary heart disease is not advisable to take this medicine.v
  • Patient with the medical history of kidney and liver dysfunction should not go for this drug as it can result in harmful effects.
  • Sinemet is not prescribed to patient with the problem of stomach ulcer.
  • This medicine is also not advised to the women who are pregnant or lactating the babies.
  • Children should be prescribed this medicine with extra precautions.
  • Alcohol should not be taken with Sinemet as it results in drowsiness and thus, patient should not drive any vehicle or do any heavy work.
  • Patient should check the expiry date of medicine before taking it.
  • Sinemet impairs the thinking and vision power of patient, hence it is advisable for them to not drive any vehicle or perform any heavy activities.

Sinemet CR

Sinemet CR is sustained release drug, which is the antidyskinetic combination of Carbidopa and Levodopa. The drug is primarily used in the management of Parkinson’s and it’s like symptoms such as stiffness, shaking or difficulty in moving the muscle. Parkinson’s disease mainly occurs when the amount of dopamine in brain gets decreased.
Levodopa when reaches brain get converted into dopamine, thus controlling the symptoms of Parkinson’s. Whereas, Carbidopa prevents the breakdown of levodopa in bloodstream; hence increasing the availability of levodopa in brain.


  • Skin rashes
  • Difficulty in breathing
  • Abnormal heart beat
  • Behavioral changes
  • Stomach pain
  • Bloody vomiting
  • Yellowing of skin and eyesv
  • Tiredness
  • Dizziness
  • Tightness in chest
  • Unusual spasm of face, eyelids and other parts


  • Patient with the skin problem should not take this medicine as it can result in harmful effects.
  • Patient with the heart disease like coronary heart disease is not advisable to take this medicine.
  • Patient with the medical history of kidney and liver dysfunction should not go for this drug as it can result in harmful effects.
  • Sinemet CR is not prescribed to patient with the problem of stomach ulcer.
  • This medicine is also not advised to the women who are pregnant or lactating the babies.
  • Children should be prescribed this medicine with extra precautions.
  • Alcohol should not be taken with Sinemet CR as it results in drowsiness and thus, patient should not drive any vehicle or do any heavy work.
  • Patient should check the expiry date of medicine before taking it.
  • Sinemet CR impairs the thinking and vision power of patient, hence it is advisable for them to not drive any vehicle or perform any heavy activities.

Stalevo

Stalevo is an antidyskinetic combination of Carbidopa, Levodopa and Entacopone that is effectively used in the treatment of Parkinson’s disease. Three of them work together by increasing dopamine level in the brain, making it balanced and lessening down the symptoms of disease. Carbidopa when reaches the brain gets converted into levodopa that in turn converted into dopamine, thus increases the amount of dopamine.


Side Effects or adverse effects are the secondary response of drug other than therapeutic one, which causes trouble to patient. All medicines have some kind of their side effects that varies from patient to patient.

More common side effects:
  • Abnormal muscle movements
  • Pain in muscle or bone
  • Diarrhea
  • Nausea
  • Discoloration of urine

Common Side Effects may include:
  • Declined blood pressure
  • Anemia
  • Abnormal body movements
  • Visionary trouble
  • Stomach disturbance
  • Dry mouth and difficulty in sleeping
  • Excessive amount of sweating
  • Tremor


Presence of some of the medical conditions can cause harmful consequences if Stalevo is taken. Patient should openly talk to their doctor regarding any of the serious medical history.

  • Women those who are pregnant, planning to become pregnant or are breast feeding are not prescribed with this medicine as it affect the baby.
  • Stalevo is not given along with any other prescribed or non prescribed medicine or any herbal medicine and diet supplements.
  • Patient who are allergic to any of the drug present in Stalevo or any kind of food are advised to not take this medicine.
  • Person with the medical history of heart disease, kidney or liver problem and lung impairment are not given this medicine as it worsens the condition.
  • Patient with the stomach disturbance or having any kind of surgery are also not suggested with Stalevo.

Symmetrel

Symmetrel is a drug recommended for the treatment of Parkinson’s disease and its symptoms like stiffness and shaking that may be caused by certain drugs. Basically, Symmetrel comprises Amantadine as a basic component which is meant for the treatment of viral infection caused by influenza A. But, this drug has also proven to be effective in treatment of stiffness of the body that occurs in condition of Parkinson’s disease. Its working is believed to be based on blocking the action of virus in body.


Some serious adverse reactions:
  • Breath shortness
  • Swelling of face, tongue or lips
  • Rapid weight gain
  • Depression
  • Behavior changes
  • Hallucination and anxiety
  • Uncontrollable muscle movement of eyes,
    tongue, jaw or neck
  • Tremor
  • High fever and excessive sweating

Less serious side effects:
  • Dizziness or drowsiness
  • Insomnia (lack of sleep)
  • Nervousness
  • Nausea or vomiting
  • Stomach disturbance
  • Dry mouth or nose
  • Loss of balance or coordination


Some important safety information:
  • Symmetrel impair the thinking and vision power of patient, hence it is advisable for them to not drive any vehicle or perform any heavy activities.
  • Women who are planning to get pregnant or are pregnant should not take this medicine. The lactating mothers are also not prescribed with this medicine.
  • Patient with the history of heart disease, lung disorder and liver or kidney dysfunction should not be dispensed with this medicine.
  • Person who is already suffering from stomach problems are not advised to take medicine as it can worsen the condition.
  • Extra precaution has to be taken while giving this medicine to the children.


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