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Home » Pharma Products » Anti Depressant Drugs

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Anti Depressant Drugs

Anti Depressant Drugs are the drugs, specially developed for the treatment of major depressive disorder and other conditions, including anxiety disorders, dysthymia, eating disorders, chronic pain, obsessive compulsive disorder and neuropathic pain. Expert studies have also shown excellent efficacy of these drugs in snoring, migraine, dysmenorrhoea, substance abuse, and attention-deficit hyperactivity disorder (ADHD) and sleep disorders. We have a variety of drugs for depression that belong to different group of drugs such as selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors (MAOIs). Some of the common side effects associated with our anti depressant drugs are change in weight, Dry mouth, sore throat, dizziness, nausea, hallucination, vomiting, ringing in the ears and headache.

Anafranil

Anafranil contains clomipramine hydrochloride as the main ingredient. It is an antiobsessional drug, recommended for the treatment of obsessive-compulsive disorder (OCD). This is a tricyclic antidepressant that effectively works by increasing the activity of certain chemicals in the brain that responsible for alleviating the mood. It belongs to the class (dibenzazepine) of pharmacologic agents known as tricyclic antidepressants.


Call your doctor at once if you have:
  • Rapid heart rate, tremors or shaking
  • Tired feeling, weakness, easy bruising or bleeding (nosebleed, bleeding gums)
  • Pale skin, feeling light-headed or short of breath
  • Confusion, extreme fear, thoughts of hurting yourself
  • Agitation, hallucinations, fever, overactive reflexes, vomiting, diarrhea, loss of coordination, fainting
  • Painful or difficult urination
  • Very stiff (rigid) muscles
  • Seizure (convulsions)n
Common side effects may include:
  • Decreased sex drive, impotence, or difficulty having an orgasm
  • Sleep problems (insomnia)
  • Appetite or weight changes
  • Memory problems, trouble concentrating
  • Dry mouth, nausea, upset stomach, loss of appetite, constipation
  • Feeling anxious, restless, dizzy, drowsy, or tired
  • Increased sweating, numbness or tingling
  • Vision changes

    Some medical conditions may interact with Anafranil. Tell your doctor or pharmacist if you have any medical conditions:
  • If you are taking a medicine that contains methylene blue
  • If you drink alcohol or have a history of alcohol abuse
  • If you are pregnant, planning to become pregnant, or are breast-feeding
  • If you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • If you take thyroid medicine or have a history of an overactive thyroid
  • If you have a history of adrenal gland problems, glaucoma or increased eye pressure, heart problems, kidney or liver problems, diabetes, seizures, trouble urinating, the blood disease porphyria, or other blood problems
  • If you have allergies to medicines, foods, or other substances
  • If you are undergoing electroshock therapy or you are scheduled to have any surgery
  • If you have a history of suicidal thoughts or behavior, bipolar disorder, or any other mental disorders

Some medicines may interact with Anafranil. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Buspirone, haloperidol, lithium, methylphenidate, phenothiazines (eg, chlorpromazine), propafenone, cimetidine, fentanyl, flecainide, serotonin-norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine), quinidine, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), St. John's wort, tramadol, triptans (eg, sumatriptan), or tryptophan
  • Linezolid or MAOIs (eg, phenelzine)
  • Barbiturates (eg, phenobarbital) or phenytoin
  • Anticholinergics (eg, benztropine), anticoagulants (eg, warfarin), carbamazepine, digoxin, or sympathomimetics (eg, phenylephrine)
  • Clonidine, guanethidine, or guanfacine
  • Do not use clomipramine if you have taken an MAO inhibitor in the past 14 days

Some important points to be taken care of:
  • Family and caregivers must closely watch patients who take Anafranil
  • It is important to keep in close contact with the patient's doctor
  • Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior
  • Anafranil is not approved for use in all children

Aventyl

Aventyl belongs to a class of medications called tricyclic antidepressants. The medication is highly recommended for people in depression. It works by increasing the activity of certain chemicals (neurotransmitters) in the brain that help elevate mood. Other than this, it is also prescribed for the treatment of several mental and mood problems. It is not only effective in depression and mental problems but is also used for nerve pain (such as peripheral neuropathy, postherpetic neuralgia), anxiety, panic disorder, or to help quit smoking.


Common side effects associated with aventyl are as follows:
  • Fast heart rate
  • Urinary retention
  • Dry mouth
  • Low blood pressure on standing
    (orthostatic hypotension)
  • Constipation
  • Blurred vision
  • Weight gain or loss

Rare effects include:
  • Rash
  • Hives
  • Seizures
  • Hepatitis

  • Before using this medication, disclose all the following details to your doctor
  • If you are pregnant, planning to become pregnant, or are breast-feeding
  • If you are allergic to any ingredient in Aventyl
  • If you are recovering from a recent heart attack
  • If you have allergies to medicines, foods, or other substances
  • If you are taking a medicine that contains methylene blue
  • If you have a history of suicidal thoughts or behavior, bipolar disorder, or any other mental disorders; you are undergoing electroshock therapy; or you are scheduled to have any surgery

Aygestin

Aygestin contains norethindrone and a synthetic, orally active progestin (17-hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one acetate). It is specially intended for the treatment of certain menstrual problems or uterine problems such as abnormal bleeding and endometriosis in which the tissue that lines the inside of the uterus is found outside the uterus in the abdomen/pelvic area. This causes painful or irregular periods. The drug effectively works by altering the lining of the uterus.


Serious side effects:
  • Pain or swelling in one or both legs
  • Migraine headache
  • Swelling in your hands or feet, rapid weight gain
  • Sudden numbness or weakness, especially on one side of the body
  • Sudden headache, confusion, pain behind the eyes, problems with vision, speech, or balance
  • Symptoms of depression (sleep problems, weakness, mood changes)
  • Severe pelvic pain
  • Chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling
  • Nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)

Less serious side effects may include:
  • Mild nausea, vomiting, bloating, stomach cramps
  • Vaginal itching or discharge
  • Skin itching or rash
  • Breast pain, swelling, or tenderness
  • Dizziness
  • Freckles or darkening of facial skin
  • Changes in your menstrual periods, decreased sex drive
  • Mild headache
  • Increased acne or hair growth
  • Changes in weight

Before taking this medication, tell your doctor if you are:
  • Allergic to any ingredient in Aygestin
  • Undiagnosed with abnormal vaginal bleeding or are postmenopausal
  • Have a history of blood clotting problems, severe blood clots (eg, in the lungs, legs, eyes), certain blood vessel problems (eg, bleeding in the brain, heart attack, stroke), or breast cancer
  • Have decreased liver function or active liver disease

Important safety information:
  • It may cause dizziness and this condition may be worse if you take it with alcohol or certain medicines
  • It may cause dark skin patches on the face, avoid sun, tanning booths and sun lamps
  • It may interfere with certain lab tests
  • For diabetic patients, it may affect the blood sugar level
  • Should not be used in children
  • Do not use this medication if you are pregnant or breastfeeding

Celexa

Citalopram HBr is the main ingredient in Celexa. An orally administered selective serotonin reuptake inhibitor (SSRI), this medication is specially intended for the people who are undergoing treatment for depression. It works by improving your energy level and helping to restore the balance of a certain natural substance (serotonin) in the brain. Other than depression, the medicine is also used to treat other mental conditions such as obsessive-compulsive disorder, panic disorder and hot flashes that occur with menopause.


Call your doctor at once if you have:
  • Low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, vomiting, feeling unsteady
  • Severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out
  • High levels of serotonin in the body - agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting
  • Blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
  • Headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats
Common Celexa side effects may include:
  • Anxiety, feeling shaky
    or sleep problems (insomnia)
  • Increased sweating
  • Changes in weight
  • Drowsiness, dizziness, weakness
  • Cold symptoms such as stuffy nose,
    sneezing, sore throat, cough
  • Decreased sex drive, impotence,
    or difficulty having an orgasm
  • Vision changes
  • Nausea, loss of appetite,
    diarrhea, constipation
  • Dry mouth, yawning

  • You should not use Celexa if you are on pimozide, or being treated with methylene blue injection
  • Do not use Celexa if you have used an MAO inhibitor in the past 14 days
  • Your family or other caregivers should also be alert to changes in your mood or symptoms
  • Report to doctor about any new or worsening symptoms such as anxiety, panic attacks, mood or behavior changes or if you feel impulsive, irritable, trouble sleeping, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself
  • It is not recommended for anyone younger than 18 years old without the advice of a doctor

Cymbalta

Cymbalta are duloxetine delayed-release capsules that belong to a group of medicines known as selective serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressants. This medication is generally prescribed for treating anxiety disorder, depression and pain. In addition to this, it is also recommended for use in adults to treat fibromyalgia that is a chronic pain disorder. The drug is also effective in providing relief from pain caused by nerve damage in people with diabetes (diabetic neuropathy) and osteoarthritis.


Call your doctor at once if you have:
  • Painful or difficult urination
  • Liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
  • A light-headed feeling, like you might pass out
  • Blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
  • Easy bruising, unusual bleeding
  • High levels of serotonin in the body - agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting
  • Low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady
  • Severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors
  • Severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or
  • purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling
    Common Cymbalta side effects may include:
  • Dry mouth
  • Drowsiness, dizziness
  • Vision changes
  • Tired feeling
  • Increased sweating
  • Loss of appetite


  • Cymbalta should not be used if you have untreated or uncontrolled glaucoma, or if are on thioridazine
  • Do not use Cymbalta if you have taken MAO inhibitor in the past 14 days as this can cause a dangerous drug interaction
  • Your doctor will need to check your progress at regular visits while you are using Cymbalta
  • Utmost attention is required to changes in your mood or symptoms
  • Report any new or worsening symptoms like mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself to your doctor
  • Try to take the medicine at the same time each day
  • Do not crush, chew, break, or open an extended-release capsule
  • It may take 4 weeks or longer before your symptoms improve. Keep using the medication as directed

Desyrel

Desyrel is an antidepressant, containing trazodone hydrochloride as its main ingredient. It generally increases the activity of chemical (serotonin) present in brain that is responsible to elevate mood. The medicine is a good recommended for the treatment of depression and other problems like anxiety disorder, sleeplessness, tension and chronic pain. Available in 50 mg, 100 mg, 150 mg, and 300 mg tablets for oral administration, this medicine is chemically unrelated to the selective serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs) or the monoamine oxidase inhibitors (MAO inhibitors).


Serious side effects that should be encountered with immediate medical help:
  • Headache, trouble concentrating, memory problems, weakness, loss of appetite, feeling unsteady, seizure, shallow breathing or breathing that stops
  • Chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling
  • Extreme mood swings, restlessness, or sleep problems
  • Dizziness, fainting, fast or pounding heartbeat
  • Easy bruising or bleeding
  • Agitation, hallucinations, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination
  • Very stiff (rigid) muscles, high fever, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out
    Less serious side effects are as follows:
  • Drowsiness
  • Mild headache
  • Constipation
  • Blurred vision


Consult your doctor, before taking this medication, if you have ony of the following conditions:
  • If you are allergic to any of the ingredients in Desyrel or to nefazodone
  • If you have taken linezolid or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
  • If you had a recent heart attack
  • If you are pregnant or breast feeding
  • If you have bipolar disorder (manic depression), heart disease or "Long QT syndrome," liver or kidney disease
  • If you have a history of drug abuse or suicidal thoughts
  • If you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself
    Important safety notes:
  • Desyrel may cause drowsiness, dizziness, or blurred vision that gets worse if you take it with alcohol or certain medicines
  • Watch all patients who take Desyrel closely especially children, teenagers and young adults who are at increased risk for suicidal thoughts or actions
  • Serotonin syndrome is a possibly fatal syndrome that is caused if you take this medication along with certain other medicines (eg, "triptans," MAOIs)
  • It may increase the risk of bleeding, that can be life- threatening

Effexor

Effexor, an excellent antidepressant that belongs to a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). The neurotransmitters are the chemicals that nerves within the brain make and release in order to communicate with one another. The main ingredient in the medication is Venlafaxine directly affects these chemicals present in brain that may become unbalanced and causing depression. It is specially recommended to people suffering from anxiety, major depressive disorder and panic disorder.


Call your doctor at once if you have:
  • Low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady
  • Severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out
  • Blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
  • Easy bruising
  • Cough, chest tightness, trouble breathing
  • Seizure (convulsions)
  • High levels of serotonin in the body - agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting
    Common Effexor side effects may include:
  • Vision changes
  • Sleep problems (insomnia), strange dreams, tired feeling
  • Increased sweating
  • Decreased sex drive, impotence, or difficulty having an orgasm
  • Nausea, vomiting, diarrhea
  • Changes in appetite or weight
  • Dry mouth, yawning
  • Dizziness, headache, anxiety, feeling nervous
  • Fast heartbeats, tremors or shaking


Effexor is not recommended in following cases:
  • If you have uncontrolled narrow-angle glaucoma
  • If you are being treated with methylene blue injection
  • If you have taken an MAO inhibitor in the past 14 days
  • If you are witnessing any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself
  • If you are younger than 18 years of age
  • If you are allergic to venlafaxine or desvenlafaxine (Pristiq)

Effexor Xr

Effexor Xr is specially intended for treating generalized or social anxiety disorder, depression or panic disorder. It is a serotonin-norepinephrine reuptake inhibitor (SNRI) that works by restoring the balance of certain natural substances in the brain (serotonin and norepinephrine) that are responsible for improving certain mood problems. It may also decrease fear, anxiety, unwanted thoughts, and the number of panic attacks. This medication is also recommended for the treatment of nerve pain and hot flashes that occur with menopause.


Check with your doctor if these side effects persist, or become overly troublesome:
  • Drowsiness, weakness,
    or fatigue
  • Dizziness, blurred vision
  • Loss of appetite
  • Heartburn
  • Unusual dreams
  • Insomnia
  • Sexual dysfunction
  • Tremors, shaking, chills
  • Tingling sensations
  • Heartburn
  • Weight loss
  • Increased sweating
  • Headaches
  • Nausea
  • Vomiting
  • Constipation
  • Diarrhea
  • Dry mouth
  • Chills
  • Gas or stomach pain
  • Runny nose
    Call your doctor or get immediate medical help if you experience any of these serious side effects:
  • Increased cholesterol
  • Narrow-angle glaucoma, enlarged pupils
  • Symptoms of serotonin syndrome, including agitation, hallucinations, coma, muscle twitching, rapid heartbeat, compromised coordination, high or low blood pressure, excessive sweating or fever
  • Abnormal bleeding, increased bruising
  • Severe allergic reactions
  • Low-salt (sodium) levels in the blood
  • Seizures or convulsions
  • Chest discomfort, or difficulty breathing


Before taking this medication, consult your doctor if you have any of the following conditions:
  • If you are allergic to any ingredient in Effexor XR extended-release capsules
  • If you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine, selegiline) within the last 14 days
  • If you are taking linezolid or medicines for weight loss
  • If you are pregnant, planning to become pregnant, or are breast-feeding
  • If you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • If you have allergies to medicines, foods, or other substances
  • If you or a family member has a history of bipolar disorder (manic-depression), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse
  • If you have a history of seizures, heart problems (eg, heart failure, irregular heartbeat), abnormal electrocardiograms (ECGs), a recent heart attack, high blood pressure, high cholesterol, an overactive thyroid, liver problems, lung problems, kidney problems, stomach or bowel bleeding, blood or bleeding problems, diabetes, increased eye pressure or glaucoma, nervous system problems, or metabolism problems
  • If you are dehydrated, have low blood sodium levels, or drink alcohol
  • If you will be having electroconvulsive therapy (ECT)
  • If you are taking a medicine that contains methylene blue

Elavil

Belonging to a group of drugs called tricyclic antidepressants, Elavil contains amitriptyline HCl that affects the chemicals in the brain that may become unbalanced and causing depression. This medicine is available as 10 mg, 25 mg, 50 mg, 75 mg, 100 mg, and 150 mg tablets and as a sterile solution for intramuscular use. It not only treats mental or mood problems such as depression but also help to improve mood and feelings of well-being, relieve anxiety and tension, help you sleep better, and increase your energy level. Moreover, the medication is also recommended for the treatments of nerve pain (such as peripheral neuropathy, postherpetic neuralgia), eating disorder (bulimia), other mental/mood problems (such as anxiety, panic disorder), or to prevent migraine headaches.


Call your doctor at once if you have any of these serious side effects:
  • Fast, pounding, or uneven heart rate, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling
  • Extreme thirst with headache, nausea, vomiting, and weakness
  • Urinating less than usual or not at all
  • Sudden numbness or weakness, especially on one side of the body
  • Sudden headache, confusion, problems with vision, speech, or balance
  • Hallucinations, or seizures (convulsions), feeling light-headed, fainting
  • Restless muscle movements in your eyes, tongue, jaw, or neck, uncontrollable shaking or tremor
  • Skin rash, severe tingling, numbness, pain, muscle weakness
  • Easy bruising or bleeding
Less serious side effects may include:
  • Nausea, vomiting, constipation, diarrhea, loss of appetite
  • Blurred vision, headache, ringing in your ears
  • Breast swelling (in men or women)
  • Decreased sex drive, impotence, or difficulty having an orgasm
  • Dry mouth, unpleasant taste
  • Feeling dizzy, drowsy, or tired
  • Trouble concentrating
  • Nightmares


Do not use this medicine, in any of the following cases:
  • If you are allergic to amitriptyline
  • If you have recently had a heart attack
  • If you have taken cisapride (Propulsid) or used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days
  • If you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself
  • If you are allergic to it, or to other tricyclic antidepressants (such as nortriptyline), or if you have any other allergies
  • If you have medical history of bleeding problems, breathing problems, liver problems, recent heart attack, problems urinating (such as due to enlarged prostate), overactive thyroid (hyperthyroidism), a certain eye problem (glaucoma)

Lexapro

Lexapro contains escitalopram oxalate as the main ingredient in its composition. It belongs to a group of drugs called selective serotonin reuptake inhibitors (SSRIs). The medication is intended for the treatment of anxiety in adults and major depressive disorder in adults and adolescents who are at least 12 years old. Chemically similar to citalopram (Celexa), the drug directly affects the neurotransmitters in the brain that are used by the nerves to communicate with one another. This medication is intended to prevent the reuptake of a neurotransmitter called serotonin.


Call your doctor at once if you have:
  • Nausea, vomiting, diarrhea, loss of appetite, feeling unsteady, loss of coordination
  • Racing thoughts, unusual risk-taking behavior, feelings of extreme happiness or sadness
  • Blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights
  • Severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out
  • Low levels of sodium in the body - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady
Common Lexapro side effects may include:
  • Sleep problems (insomnia)
  • Vision changes
  • Drowsiness, tired feeling
  • Weight changes
  • Decreased sex drive, impotence, or difficulty having an orgasm
  • Mild nausea, gas, heartburn, upset stomach, constipation
  • Increased sweating


You should not use Lexapro, in any of the following cases:
  • If you also take pimozide, or if you are being treated with methylene blue injection
  • If you have taken an MAO inhibitor in the past 14 days
  • If you are under 12 years
  • If you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself
  • If you are pregnant or breastfeeding

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